| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Cyclin Y (60-120) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CCNY |
| Gene ID: |
219771 |
| Uniprot ID: |
CCNY_HUMAN |
| Immunogen Region: |
60-120 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 60-120 of human CCNY (NP_859049.2). |
| Immunogen Sequence: |
PNLKYTIKCVALAIYYHIKN RDPDGRMLLDIFDENLHPLS KSEVPPDYDKHNPEQKQIYR F |
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Ubiquitinated.leading to its degradation. Heavily phosphorylated. Phosphorylation at Ser-71 and Ser-73 by CDK14 is enhanced during the G2 and M cell cycle phases, and creates a phosphodegron triggering SCF-dependent ubiquitination. |
| Function | Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. |
| Protein Name | Cyclin-YCyc-YCyclin Box Protein 1Cyclin Fold Protein 1Cyclin-X |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideIsoform 3: Nucleus |
| Alternative Antibody Names | Anti-Cyclin-Y antibodyAnti-Cyc-Y antibodyAnti-Cyclin Box Protein 1 antibodyAnti-Cyclin Fold Protein 1 antibodyAnti-Cyclin-X antibodyAnti-CCNY antibodyAnti-C10orf9 antibodyAnti-CBCP1 antibodyAnti-CFP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
