| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CUEDC2 (1-150) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CUEDC2 |
| Gene ID: |
79004 |
| Uniprot ID: |
CUED2_HUMAN |
| Immunogen Region: |
1-150 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human CUEDC2 (NP_076945.2). |
| Immunogen Sequence: |
MELERIVSAALLAFVQTHLP EADLSGLDEVIFSYVLGVLE DLGPSGPSEENFDMEAFTEM MEAYVPGFAHIPRGTIGDMM QKLSGQLSDARNKENLQPQS SGVQGQVPISPEPLQRPEML KEETRSSAAAAADTQDEATG AEEELLPGVD |
| Tissue Specificity | Significantly up-regulated in breast tumor tissues compared with matched adjacent normal tissues (at protein level). Levels inversely correlate with ESR1 in breast cancers and are lower in low-grade tumors compared to high-grade tumors. |
| Function | Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism. |
| Protein Name | Cue Domain-Containing Protein 2 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Cue Domain-Containing Protein 2 antibodyAnti-CUEDC2 antibodyAnti-C10orf66 antibodyAnti-HOYS6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
