| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CUEDC2 |
| Gene ID: | 79004 |
| Uniprot ID: | CUED2_HUMAN |
| Immunogen Region: | 1-150 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human CUEDC2 (NP_076945.2). |
| Immunogen Sequence: | MELERIVSAALLAFVQTHLP EADLSGLDEVIFSYVLGVLE DLGPSGPSEENFDMEAFTEM MEAYVPGFAHIPRGTIGDMM QKLSGQLSDARNKENLQPQS SGVQGQVPISPEPLQRPEML KEETRSSAAAAADTQDEATG AEEELLPGVD |
| Tissue Specificity | Significantly up-regulated in breast tumor tissues compared with matched adjacent normal tissues (at protein level). Levels inversely correlate with ESR1 in breast cancers and are lower in low-grade tumors compared to high-grade tumors. |
| Function | Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism. |
| Protein Name | Cue Domain-Containing Protein 2 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Cue Domain-Containing Protein 2 antibodyAnti-CUEDC2 antibodyAnti-C10orf66 antibodyAnti-HOYS6 antibody |
Information sourced from Uniprot.org