| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-USP20 (1-150) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
USP20 |
| Gene ID: |
10868 |
| Uniprot ID: |
UBP20_HUMAN |
| Immunogen Region: |
1-150 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human USP20 (NP_006667.3). |
| Immunogen Sequence: |
MGDSRDLCPHLDSIGEVTKE DLLLKSKGTCQSCGVTGPNL WACLQVACPYVGCGESFADH STIHAQAKKHNLTVNLTTFR LWCYACEKEVFLEQRLAAPL LGSSSKFSEQDSPPPSHPLK AVPIAVADEGESESEDDDLK PRGLTGMKNL |
| Post Translational Modifications | Ubiquitinated via a VHL-dependent pathway for proteasomal degradation. |
| Function | Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis. Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination. Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization. Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1. Acts as a positive regulator for NF-kappa-B activation by TNF-alpha through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Deubiquitinates MCL1, a pivotal member of the anti-apoptotic Bcl-2 protein family to regulate its stability. Within the endoplasmic reticulum, participates with USP33 in the rescue of post-translationally targeted membrane proteins that are inappropriately ubiquitinated by the cytosolic protein quality control in the cytosol. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 20Deubiquitinating Enzyme 20Ubiquitin Thioesterase 20Ubiquitin-Specific-Processing Protease 20Vhl-Interacting Deubiquitinating Enzyme 2Hvdu2 |
| Database Links | Reactome: R-HSA-5689880 |
| Cellular Localisation | CytoplasmEndoplasmic ReticulumPerinuclear RegionCytoskeletonMicrotubule Organizing CenterCentrosome |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 20 antibodyAnti-Deubiquitinating Enzyme 20 antibodyAnti-Ubiquitin Thioesterase 20 antibodyAnti-Ubiquitin-Specific-Processing Protease 20 antibodyAnti-Vhl-Interacting Deubiquitinating Enzyme 2 antibodyAnti-Hvdu2 antibodyAnti-USP20 antibodyAnti-KIAA1003 antibodyAnti-LSFR3A antibodyAnti-VDU2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
