| Host: |
Rabbit |
| Applications: |
IF |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-cTNT (1-288) is suitable for use in Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TNNT2 |
| Gene ID: |
7139 |
| Uniprot ID: |
TNNT2_HUMAN |
| Immunogen Region: |
1-288 |
| Immunogen: |
Recombinant Protein corresponding to a sequence within amino acids 1-288 of human cTNT (NP_001001430.1). |
| Immunogen Sequence: |
MSDIEEVVEEYEEEEQEEAA VEEQEEAAEEDAEAEAETEE TRAEEDEEEEEAKEAEDGPM EESKPKPRSFMPNLVPPKIP DGERVDFDDIHRKRMEKDLN ELQALIEAHFENRKKEEEEL VSLKDRIERRRAERAEQQRI RNEREKERQNRLAEERARRE EEENRRKAEDEARKKKALSN MMHFGGYIQKQAQTERKSGK RQTEREKKKKILAERRKVLA IDHLNEDQLREKAKELWQS |
| Tissue Specificity | Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. |
| Post Translational Modifications | Phosphorylation at Thr-213 by PRKCA induces significant reduction in myofilament calcium sensitivity and actomyosin ATPase activity. |
| Function | Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| Protein Name | Troponin T - Cardiac MuscleTntcCardiac Muscle Troponin TCtnt |
| Database Links | Reactome: R-HSA-390522 |
| Alternative Antibody Names | Anti-Troponin T - Cardiac Muscle antibodyAnti-Tntc antibodyAnti-Cardiac Muscle Troponin T antibodyAnti-Ctnt antibodyAnti-TNNT2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
