| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CIR1 |
| Gene ID: | 9541 |
| Uniprot ID: | CIR1_HUMAN |
| Immunogen Region: | 1-160 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human CIR1 (NP_004873.3). |
| Immunogen Sequence: | MGKSFANFMCKKDFHPASKS NIKKVWMAEQKISYDKKKQE ELMQQYLKEQESYDNRLLMG DERVKNGLNFMYEAPPGAKK ENKEKEETEGETEYKFEWQK GAPREKYAKDDMNIRDQPFG IQVRNVRCIKCHKWGHVNTD RECPLFGLSGINASSVPTDG |
| Tissue Specificity | Highly expressed in heart, brain, placenta, liver, skeletal muscle and pancreas. |
| Post Translational Modifications | Phosphorylated by NEK6. |
| Function | May modulate splice site selection during alternative splicing of pre-mRNAs. Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription. |
| Protein Name | Corepressor Interacting With Rbpj 1Cbf1-Interacting CorepressorRecepin |
| Cellular Localisation | Nucleus SpeckleCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeColocalizes With Nek6 In The Centrosome |
| Alternative Antibody Names | Anti-Corepressor Interacting With Rbpj 1 antibodyAnti-Cbf1-Interacting Corepressor antibodyAnti-Recepin antibodyAnti-CIR1 antibodyAnti-CIR antibody |
Information sourced from Uniprot.org