Anti-CHD1 antibody (1501-1710) (STJ117232)

SKU:
STJ117232

Shipping:
Free Shipping
Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CHD1 (1501-1710) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CHD1
Gene ID: 1105
Uniprot ID: CHD1_HUMAN
Immunogen Region: 1501-1710
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1501-1710 of human CHD1 (NP_001261.2).
Immunogen Sequence: IKKRQESQQNSDQNSNLNPH VIRNPDVERLKENTNHDDSS RDSYSSDRHLTQYHDHHKDR HQGDSYKKSDSRKRPYSSFS NGKDHRDWDHYKQDSRYYSD REKHRKLDDHRSRDHRSNLE GSLKDRSHSDHRSHSDHRLH SDHRSSSEYTHHKSSRDYRY HSDWQMDHRASSSGPRSPLD QRSPYGSRSPFEHSVEHKST PEHTWSSRKT
Tissue Specificity Expressed in many tissues including in the brain, where the highest level of expression is found in the cerebellum and basal ganglia.
Function ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity. Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells.
Protein Name Chromodomain-Helicase-Dna-Binding Protein 1
Chd-1
Atp-Dependent Helicase Chd1
Database Links Reactome: R-HSA-9018519
Cellular Localisation Nucleus
Cytoplasm
Is Released Into The Cytoplasm When Cells Enter Mitosis And Is Reincorporated Into Chromatin During Telophase-Cytokinesis
Alternative Antibody Names Anti-Chromodomain-Helicase-Dna-Binding Protein 1 antibody
Anti-Chd-1 antibody
Anti-Atp-Dependent Helicase Chd1 antibody
Anti-CHD1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance