Host: | Rabbit |
Applications: | ELISA/IP/WB |
Reactivity: | Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Rabbit polyclonal antibody anti-CGRP (350-410) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
Purification: | Affinity Purified |
Concentration: | 0.5-1.5 µg/µl |
Dilution Range: | WB: 1:500-1:5, 000ELISA: 1:50, 000IP: 1:200 |
Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Gene Symbol: | Calca |
Gene ID: | 12310 |
Uniprot ID: | CALCA_MOUSE |
Immunogen Region: | 350-410 |
Immunogen: | Synthetic peptide corresponding to amino acids within region 350-410 mouse Calcitonin gene-related peptide 1. |
Tissue Specificity | Detected in nerve cells of cerebrum, hippocampus and pons/midbrain in newborns, and only in nerve cells of pons/midbrain in adult. |
Function | CGRP1/CALCA is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex. Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP. CGRP1 can also bind and activate CALCR-RAMP1 (AMYR1) receptor complex. |
Protein Name | Calcitonin Gene-Related Peptide 1Cgrp1Alpha-Type CgrpCalcitonin Gene-Related Peptide ICgrp-I |
Database Links | Reactome: R-MMU-418555Reactome: -MMU-419812 |
Cellular Localisation | Secreted |
Alternative Antibody Names | Anti-Calcitonin Gene-Related Peptide 1 antibodyAnti-Cgrp1 antibodyAnti-Alpha-Type Cgrp antibodyAnti-Calcitonin Gene-Related Peptide I antibodyAnti-Cgrp-I antibodyAnti-Calca antibodyAnti-Calc antibody |
Information sourced from Uniprot.org