| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CENPN (180-300) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CENPN |
| Gene ID: |
55839 |
| Uniprot ID: |
CENPN_HUMAN |
| Immunogen Region: |
180-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 180-300 of human CENPN (NP_001094094). |
| Immunogen Sequence: |
TIASKHHQIVKMDLRSRYLD SLKAIVFKQYNQTFETHNST TPLQERSLGLDINMDSRIIH ENIVEKERVQRITQETFGDY PQPQLEFAQYKLETKFKSGL NGSILAEREEPLRCLIKFSS P |
| Function | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. |
| Protein Name | Centromere Protein NCenp-NInterphase Centromere Complex Protein 32 |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-606279Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | NucleusChromosomeCentromereKinetochoreLocalizes Exclusively In The Kinetochore Domain Of CentromeresKinetochore-Bound Levels Decrease When Cells Enter Mitosis And Increase Again When Cells Exit Mitosis |
| Alternative Antibody Names | Anti-Centromere Protein N antibodyAnti-Cenp-N antibodyAnti-Interphase Centromere Complex Protein 32 antibodyAnti-CENPN antibodyAnti-C16orf60 antibodyAnti-ICEN32 antibodyAnti-BM-309 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
