| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CDCA7L (1-300) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CDCA7L |
| Gene ID: |
55536 |
| Uniprot ID: |
CDA7L_HUMAN |
| Immunogen Region: |
1-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CDCA7L (NP_061189.2). |
| Immunogen Sequence: |
MELATRYQIPKEVADIFNAP SDDEEFVGFRDDVPMETLSS EESCDSFDSLESGKQQDVRF HSKYFTEELRRIFIEDTDSE TEDFAGFTQSDLNGKTNPEV MVVESDLSDDGKASLVSEEE EDEEEDKATPRRSRSRRSSI GLRVAFQFPTKKLANKPDKN SSSEQLFSSARLQNEKKTIL ERKKDCRQVIQREDSTSESE DDSRDESQESSDALLKRTMN IKENKAMLAQLLAELNSMP |
| Tissue Specificity | Ubiquitous. Overexpressed in medulloblastoma. |
| Post Translational Modifications | Phosphorylation increases its interaction with PSIP1. |
| Function | Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways.May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1. |
| Protein Name | Cell Division Cycle-Associated 7-Like ProteinProtein Jpo2Transcription Factor Ram2 |
| Cellular Localisation | CytoplasmNucleusAssociates With ChromatinTranslocates From Cytoplasm To Nucleus Under Dexamethasone Induction |
| Alternative Antibody Names | Anti-Cell Division Cycle-Associated 7-Like Protein antibodyAnti-Protein Jpo2 antibodyAnti-Transcription Factor Ram2 antibodyAnti-CDCA7L antibodyAnti-HR1 antibodyAnti-JPO2 antibodyAnti-R1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
