| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IVNS1ABP (1-300) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IVNS1ABP |
| Gene ID: |
10625 |
| Uniprot ID: |
NS1BP_HUMAN |
| Immunogen Region: |
1-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human IVNS1ABP (NP_006460.2). |
| Immunogen Sequence: |
MIPNGYLMFEDENFIESSVA KLNALRKSGQFCDVRLQVCG HEMLAHRAVLACCSPYLFEI FNSDSDPHGISHVKFDDLNP EAVEVLLNYAYTAQLKADKE LVKDVYSAAKKLKMDRVKQV CGDYLLSRMDVTSCISYRNF ASCMGDSRLLNKVDAYIQEH LLQISEEEEFLKLPRLKLEV MLEDNVCLPSNGKLYTKVIN WVQRSIWENGDSLEELMEEV QTLYYSADHKLLDGNLLDG |
| Function | Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription. In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors. Inhibits pre-mRNA splicing (in vitro). (Microbial infection) Involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein. |
| Protein Name | Influenza Virus Ns1a-Binding ProteinNs1-BpNs1-Binding ProteinAryl Hydrocarbon Receptor-Associated Protein 3Kelch-Like Protein 39 |
| Cellular Localisation | CytoplasmCytoskeletonNucleusNucleoplasmAssociated With Actin FilamentsLocalization Related To Speckle Domains Which Correspond To Interchromatin Granules And Are Enriched In Factors Involved In Pre-Mrna SplicingFollowing Influenza A Virus InfectionRedistribution From Speckles To A More Diffuse Distribution In The Nucleoplasm |
| Alternative Antibody Names | Anti-Influenza Virus Ns1a-Binding Protein antibodyAnti-Ns1-Bp antibodyAnti-Ns1-Binding Protein antibodyAnti-Aryl Hydrocarbon Receptor-Associated Protein 3 antibodyAnti-Kelch-Like Protein 39 antibodyAnti-IVNS1ABP antibodyAnti-ARA3 antibodyAnti-FLARA3 antibodyAnti-KIAA0850 antibodyAnti-KLHL39 antibodyAnti-NS1 antibodyAnti-NS1BP antibodyAnti-HSPC068 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and BUB1 knockout (KO) HeLa cells, using [KO Validated] BUB1 Rabbit polyclonal antibody (STJ11100026) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1min.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89098/357557/STJ11100026_1__69013.1713121681.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and BUB1 knockout (KO) HeLa cells, using [KO Validated] BUB1 Rabbit polyclonal antibody (STJ11100026) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1min.")
