| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CD55 |
| Gene ID: | 1604 |
| Uniprot ID: | DAF_HUMAN |
| Immunogen Region: | 40-300 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 40-300 of human CD55 (NP_000565.1). |
| Immunogen Sequence: | PDVPNAQPALEGRTSFPEDT VITYKCEESFVKIPGEKDSV ICLKGSQWSDIEEFCNRSCE VPTRLNSASLKQPYITQNYF PVGTVVEYECRPGYRREPSL SPKLTCLQNLKWSTAVEFCK KKSCPNPGEIRNGQIDVPGG ILFGATISFSCNTGYKLFGS TSSFCLISGSSVQWSDPLPE CREIYCPAPPQIDNGIIQGE RDHYGYRQSVTYACNKGFTM IGEHSIYCTVNNDEGEWSG |
| Tissue Specificity | Expressed on the plasma membranes of all cell types that are in intimate contact with plasma complement proteins. It is also found on the surfaces of epithelial cells lining extracellular compartments, and variants of the molecule are present in body fluids and in extracellular matrix. |
| Post Translational Modifications | The Ser/Thr-rich domain is heavily O-glycosylated. |
| Function | This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage. (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5. (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable). (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21. |
| Protein Name | Complement Decay-Accelerating Factor Cd Antigen Cd55 |
| Database Links | Reactome: R-HSA-373080 Reactome: R-HSA-6798695 Reactome: R-HSA-6807878 Reactome: R-HSA-977606 |
| Cellular Localisation | Isoform 1: Cell Membrane Single-Pass Type I Membrane Protein Isoform 2: Cell Membrane Lipid-Anchor Gpi-Anchor Isoform 3: Secreted Isoform 4: Secreted Isoform 5: Secreted Isoform 6: Cell Membrane Isoform 7: Cell Membrane |
| Alternative Antibody Names | Anti-Complement Decay-Accelerating Factor antibody Anti-Cd Antigen Cd55 antibody Anti-CD55 antibody Anti-CR antibody Anti-DAF antibody |
Information sourced from Uniprot.org