| Host: |
Rabbit |
| Applications: |
FC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-Tumor Necrosis Factor Receptor Superfamily Member 5 (21-193) is suitable for use in Flow Cytometry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S3943RM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% thimerosal, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
FC 1:50-1:200 |
| Storage Instruction: |
Store at 4°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CD40 |
| Gene ID: |
958 |
| Uniprot ID: |
TNR5_HUMAN |
| Immunogen Region: |
21-193 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 21-193 of human CD40 (P25942). |
| Immunogen Sequence: |
EPPTACREKQYLINSQCCSL CQPGQKLVSDCTEFTETECL PCGESEFLDTWNRETHCHQH KYCDPNLGLRVQQKGTSETD TICTCEEGWHCTSEACESCV LHRSCSPGFGVKQIATGVSD TICEPCPVGFFSNVSSAFEK CHPWTSCETKDLVVQQAGTN KTDVVCGPQDRLR |
| Tissue Specificity | B-cells and in primary carcinomas. |
| Function | Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 5B-Cell Surface Antigen Cd40Bp50Cd40l ReceptorCdw40Cd Antigen Cd40 |
| Database Links | Reactome: R-HSA-198933 P25942-1Reactome: R-HSA-5668541 P25942-1Reactome: R-HSA-5676594 P25942-1 |
| Cellular Localisation | Isoform I: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform Ii: Secreted |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Receptor Superfamily Member 5 antibodyAnti-B-Cell Surface Antigen Cd40 antibodyAnti-Bp50 antibodyAnti-Cd40l Receptor antibodyAnti-Cdw40 antibodyAnti-Cd Antigen Cd40 antibodyAnti-CD40 antibodyAnti-TNFRSF5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
