| Host: |
Rabbit |
| Applications: |
FC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-Adp-Ribosyl Cyclase/Cyclic Adp-Ribose Hydrolase 1 (43-300) is suitable for use in Flow Cytometry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S3944RM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% thimerosal, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
FC 1:50-1:200 |
| Storage Instruction: |
Store at 4°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CD38 |
| Gene ID: |
952 |
| Uniprot ID: |
CD38_HUMAN |
| Immunogen Region: |
43-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 43-300 of human CD38 (P28907). |
| Immunogen Sequence: |
VPRWRQQWSGPGTTKRFPET VLARCVKYTEIHPEMRHVDC QSVWDAFKGAFISKHPCNIT EEDYQPLMKLGTQTVPCNKI LLWSRIKDLAHQFTQVQRDM FTLEDTLLGYLADDLTWCGE FNTSKINYQSCPDWRKDCSN NPVSVFWKTVSRRFAEAACD VVHVMLNGSRSKIFDKNSTF GSVEVHNLQPEKVQTLEAWV IHGGREDSRDLCQDPTIKEL ESIISKRNIQFSCKNIYRP |
| Tissue Specificity | Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. |
| Function | Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion. Synthesizes the Ca(2+) mobilizer nicotinate-adenine dinucleotide phosphate, NAADP(+), from 2'-phospho-cADPR and nicotinic acid, as well as from NADP(+) and nicotinic acid. At both pH 5.0 and pH 7.4 preferentially transforms 2'-phospho-cADPR into NAADP(+), while preferentially cleaving NADP(+) to cADPR and ADPRP rather than into NADDP(+). Has cADPR hydrolase activity. |
| Protein Name | Adp-Ribosyl Cyclase/Cyclic Adp-Ribose Hydrolase 12'-Phospho-Adp-Ribosyl Cyclase2'-Phospho-Adp-Ribosyl Cyclase/2'-Phospho-Cyclic-Adp-Ribose Transferase2'-Phospho-Cyclic-Adp-Ribose TransferaseAdp-Ribosyl Cyclase 1Adprc 1Cyclic Adp-Ribose Hydrolase 1Cadpr Hydrolase 1T10Cd Antigen Cd38 |
| Database Links | Reactome: R-HSA-196807 |
| Cellular Localisation | Cell SurfaceMembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Adp-Ribosyl Cyclase/Cyclic Adp-Ribose Hydrolase 1 antibodyAnti-2'-Phospho-Adp-Ribosyl Cyclase antibodyAnti-2'-Phospho-Adp-Ribosyl Cyclase/2'-Phospho-Cyclic-Adp-Ribose Transferase antibodyAnti-2'-Phospho-Cyclic-Adp-Ribose Transferase antibodyAnti-Adp-Ribosyl Cyclase 1 antibodyAnti-Adprc 1 antibodyAnti-Cyclic Adp-Ribose Hydrolase 1 antibodyAnti-Cadpr Hydrolase 1 antibodyAnti-T10 antibodyAnti-Cd Antigen Cd38 antibodyAnti-CD38 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
