| Post Translational Modifications | On IL4 binding, phosphorylated on C-terminal tyrosine residues. Phosphorylation on any one of tyrosine residues, Tyr-575, Tyr-603 or Tyr-631, is required for STAT6-induced gene induction. The soluble form (sIL4R/IL4BP) can also be produced by proteolytic cleavage at the cell surface (shedding) by a metalloproteinase. |
| Function | Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells. |
| Protein Name | Interleukin-4 Receptor Subunit AlphaIl-4 Receptor Subunit AlphaIl-4r Subunit AlphaIl-4r-AlphaIl-4raCd Antigen Cd124 Cleaved Into - Soluble Interleukin-4 Receptor Subunit AlphaSoluble Il-4 Receptor Subunit AlphaSoluble Il-4r-AlphaSil4ralpha/ProtIl-4-Binding ProteinIl4-Bp |
| Database Links | Reactome: R-HSA-6785807 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Secreted |
| Alternative Antibody Names | Anti-Interleukin-4 Receptor Subunit Alpha antibodyAnti-Il-4 Receptor Subunit Alpha antibodyAnti-Il-4r Subunit Alpha antibodyAnti-Il-4r-Alpha antibodyAnti-Il-4ra antibodyAnti-Cd Antigen Cd124 Cleaved Into - Soluble Interleukin-4 Receptor Subunit Alpha antibodyAnti-Soluble Il-4 Receptor Subunit Alpha antibodyAnti-Soluble Il-4r-Alpha antibodyAnti-Sil4ralpha/Prot antibodyAnti-Il-4-Binding Protein antibodyAnti-Il4-Bp antibodyAnti-IL4R antibodyAnti-IL4RA antibodyAnti-582J2.1 antibody |
Information sourced from Uniprot.org
![Anti-CD124/IL4R/IL-4R Alpha nanobody [SAA1420] (STJN000528)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/201141/413240/STJN000528-SDS-PAGE-1__72088.1749232728.jpg?c=1 "Anti-CD124/IL4R/IL-4R Alpha nanobody [SAA1420] (STJN000528)")