| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
CACNA1A |
| Gene ID: |
773 |
| Uniprot ID: |
CAC1A_HUMAN |
| Immunogen Region: |
2000-2100 aa |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 2000-2100 of human CACNA1A (NP_075461.2). |
| Immunogen Sequence: |
SPTQEGGPGQNALPSTQLDP GGALMAHESGLKESPSWVTQ RAQEMFQKTGTWSPEQGPPT DMPNSQPNSQSVEMREMGRD GYSDSEHYLPMEGQGRAASM P |
| Tissue Specificity | Brain specific.mainly found in cerebellum, cerebral cortex, thalamus and hypothalamus. Expressed in the small cell lung carcinoma cell line SCC-9. No expression in heart, kidney, liver or muscle. Purkinje cells contain predominantly P-type VSCC, the Q-type being a prominent calcium current in cerebellar granule cells. |
| Function | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by the spider omega-agatoxin-IVA (AC P54282). They are however insensitive to dihydropyridines (DHP). |
| Protein Name | Voltage-Dependent P/Q-Type Calcium Channel Subunit Alpha-1aBrain Calcium Channel IBiCalcium Channel - L Type - Alpha-1 Polypeptide Isoform 4Voltage-Gated Calcium Channel Subunit Alpha Cav2.1 |
| Database Links | Reactome: R-HSA-112308Reactome: R-HSA-422356 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Voltage-Dependent P/Q-Type Calcium Channel Subunit Alpha-1a antibodyAnti-Brain Calcium Channel I antibodyAnti-Bi antibodyAnti-Calcium Channel - L Type - Alpha-1 Polypeptide Isoform 4 antibodyAnti-Voltage-Gated Calcium Channel Subunit Alpha Cav2.1 antibodyAnti-CACNA1A antibodyAnti-CACH4 antibodyAnti-CACN3 antibodyAnti-CACNL1A4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
