| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | BRAT1 |
| Gene ID: | 221927 |
| Uniprot ID: | BRAT1_HUMAN |
| Immunogen Region: | 652-821 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 652-821 of human BRAT1 (NP_689956.2). |
| Immunogen Sequence: | AQGLELALVFLGQTLGPPRT HCPYAVALPEVAPAQPLTEA LRALCHVGLFDFAFCALFDC DRPVAQKSCDLLLFLRDKIA SYSSLREARGSPNTASAEAT LPRWRAGEQAQPPGDQEPEA VLAMLRSLDLEGLRSTLAES SDHVEKSPQSLLQDMLATGG FLQGDEADCY |
| Tissue Specificity | Ubiquitously expressed. |
| Post Translational Modifications | Ubiquitinated by NEDD4, NEDD4L and ITCH.mono- and polyubiquitinated forms are detected. |
| Function | Involved in DNA damage response.activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress. Plays a role in regulating mitochondrial function and cell proliferation. Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors. |
| Protein Name | Brca1-Associated Atm Activator 1Brca1-Associated Protein Required For Atm Activation Protein 1 |
| Cellular Localisation | NucleusCytoplasmPresent At Double Strand Breaks (Dsbs)Following Ionizing Radiation TreatmentThe Ubiquitinated Form Localizes In The Nucleus In A Ndfip1-Dependent Manner |
| Alternative Antibody Names | Anti-Brca1-Associated Atm Activator 1 antibodyAnti-Brca1-Associated Protein Required For Atm Activation Protein 1 antibodyAnti-BRAT1 antibodyAnti-BAAT1 antibodyAnti-C7orf27 antibody |
Information sourced from Uniprot.org