| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-BFSP1 (281-540) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BFSP1 |
| Gene ID: |
631 |
| Uniprot ID: |
BFSP1_HUMAN |
| Immunogen Region: |
281-540 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 281-540 of human BFSP1 (NP_001155177.1). |
| Immunogen Sequence: |
EESESKFESESKEVSPLTQE GAPEDVPDGGQISKGFGKLY RKVKEKVRSPKEPETPTELY TKERHVLVTGDANYVDPRFY VSSITAKGGVAVSVAEDSVL YDGQVEPSPESPKPPLENGQ VGLQEKEDGQPIDQQPIDKE IEPDGAELEGPEEKREGEER DEESRRPCAMVTPGAEEPSI PEPPKPAADQDGAEVLGTRS RSLPEKGPPKALAYKTVEVV ESIEKISTESIQTYEETAV |
| Tissue Specificity | Expressed in the cortex and nucleus of the retina lens (at protein level). |
| Post Translational Modifications | Proteolytically cleaved during lens cell fiber differentiation with increased fragmentation as fiber cell age increases. Filensin C-terminal fragment: Myristoylated at Gly-434 following proteolytic cleavage at Asp-433. Filensin N-terminal fragment: Acetylated at Ala-42 following proteolytic cleavage at Leu-41. |
| Function | Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA. Involved in altering the calcium regulation of MIP water permeability. |
| Protein Name | FilensinBeaded Filament Structural Protein 1Lens Fiber Cell Beaded-Filament Structural Protein Cp 115Cp115Lens Intermediate Filament-Like HeavyLifl-H Cleaved Into - Filensin C-Terminal Fragment - Filensin N-Terminal Fragment |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytoskeletonCell Cortex |
| Alternative Antibody Names | Anti-Filensin antibodyAnti-Beaded Filament Structural Protein 1 antibodyAnti-Lens Fiber Cell Beaded-Filament Structural Protein Cp 115 antibodyAnti-Cp115 antibodyAnti-Lens Intermediate Filament-Like Heavy antibodyAnti-Lifl-H Cleaved Into - Filensin C-Terminal Fragment - Filensin N-Terminal Fragment antibodyAnti-BFSP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
