| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
BEND3 |
| Gene ID: |
57673 |
| Uniprot ID: |
BEND3_HUMAN |
| Immunogen Region: |
596-828 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 596-828 of human BEND3 (NP_001073919.1). |
| Immunogen Sequence: |
NCSGSLGKKQLDPSRIKLIR HYVQLLYPRAKNDRVWTLEF VGKLDERCRRRDTEQRRSYQ QQRKVHVPGPECRDLTSYAI NPERFREEFEGPPLPPERSS KDFCKIPLDELVVPSPDFPV PSPYLLSDKEVREIVQQSLS VGNFAARLLVRLFPELFTAE NLRLQYNHSGACNKKQLDPT RLRLIRHYVEAVYPVEKMEE VWHYECIPSIDERCRRPNRK KCDILKKAKKVEK |
| Tissue Specificity | Expressed at least in heart, kidney, liver, ovary and spleen, with highest levels in spleen and lowest in heart. Expressed on the surface of T-cells. |
| Post Translational Modifications | Sumoylated at Lys-20 by SUMO1 and at Lys-512 by SUMO1, SUMO2 and SUMO3. Sumoylation probably occurs sequentially, with that of Lys-20 preceding that of Lys-512. It does not alter association with heterochromatin, but is required for the repression of transcription. |
| Function | Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination. Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites. Stimulates the ERCC6L translocase and ATPase activities. |
| Protein Name | Ben Domain-Containing Protein 3 |
| Cellular Localisation | NucleusNucleolusIn The NucleusObserved In Heterochromatic Foci Containing Cbx1Cbx3Cbx5 And Histone H3 Trimethylated At 'Lys-9'Released From Chromatin During DecondensationAssociation With Heterochromatin Does Not Depend On Sumoylation |
| Alternative Antibody Names | Anti-Ben Domain-Containing Protein 3 antibodyAnti-BEND3 antibodyAnti-KIAA1553 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
