| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-BCAN (762-911) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | BCAN |
| Gene ID: | 63827 |
| Uniprot ID: | PGCB_HUMAN |
| Immunogen Region: | 762-911 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 762-911 of human BCAN (NP_068767.3). |
| Immunogen Sequence: | VPLLYENWNPGQPDSYFLSG ENCVVMVWHDQGQWSDVPCN YHLSYTCKMGLVSCGPPPEL PLAQVFGRPRLRYEVDTVLR YRCREGLAQRNLPLIRCQEN GRWEAPQISCVPRRPARALH PEEDPEGRQGRLLGRWKALL IPPSSPMPGP |
| Tissue Specificity | Expressed in the retina, specifically in the inner nuclear layer, inner plexiform layer and ganglion cell layer (at protein level). Detected in cerebrospinal fluid (at protein level). |
| Post Translational Modifications | O-glycosylated.contains chondroitin sulfate. O-glycosylated with a core 1 or possibly core 8 glycan. |
| Function | May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans. |
| Protein Name | Brevican Core ProteinBrain-Enriched Hyaluronan-Binding ProteinBehabChondroitin Sulfate Proteoglycan 7 |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-1971475Reactome: R-HSA-2022870Reactome: R-HSA-2022923Reactome: R-HSA-2024101Reactome: R-HSA-3000178Reactome: R-HSA-3560783Reactome: R-HSA-3560801Reactome: R-HSA-3595172Reactome: R-HSA-3595174Reactome: R-HSA-3595177Reactome: R-HSA-4420332 |
| Cellular Localisation | SecretedIsoform 1: SecretedExtracellular SpaceExtracellular MatrixIsoform 2: MembraneLipid-AnchorGpi-Anchor |
| Alternative Antibody Names | Anti-Brevican Core Protein antibodyAnti-Brain-Enriched Hyaluronan-Binding Protein antibodyAnti-Behab antibodyAnti-Chondroitin Sulfate Proteoglycan 7 antibodyAnti-BCAN antibodyAnti-BEHAB antibodyAnti-CSPG7 antibodyAnti-UNQ2525 antibodyAnti-PRO6018 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and DNA Ligase IV knockout (KO) HeLa cells, using [KO Validated] DNA Ligase IV Rabbit polyclonal antibody (STJ11100023) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1min.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89095/357554/STJ11100023_1__39011.1713121676.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and DNA Ligase IV knockout (KO) HeLa cells, using [KO Validated] DNA Ligase IV Rabbit polyclonal antibody (STJ11100023) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1min.")
