| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
BABAM1 |
| Gene ID: |
29086 |
| Uniprot ID: |
BABA1_HUMAN |
| Immunogen Region: |
1-329 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-329 of human BABAM1 (NP_054892.2). |
| Immunogen Sequence: |
MEVAEPSSPTEEEEEEEEHS AEPRPRTRSNPEGAEDRAVG AQASVGSRSEGEGEAASADD GSLNTSGAGPKSWQVPPPAP EVQIRTPRVNCPEKVIICLD LSEEMSLPKLESFNGSKTNA LNVSQKMIEMFVRTKHKIDK SHEFALVVVNDDTAWLSGLT SDPRELCSCLYDLETASCST FNLEGLFSLIQQKTELPVTE NVQTIPPPYVVRTILVYSRP PCQPQFSLTEPMKKMFQCP |
| Function | Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1.deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. |
| Protein Name | Brisc And Brca1-A Complex Member 1Mediator Of Rap80 Interactions And Targeting Subunit Of 40 KdaNew Component Of The Brca1-A Complex |
| Database Links | Reactome: R-HSA-5689901Reactome: R-HSA-5693565Reactome: R-HSA-5693571Reactome: R-HSA-5693607Reactome: R-HSA-69473 |
| Cellular Localisation | CytoplasmNucleusLocalizes At Sites Of Dna Damage At Double-Strand Breaks (Dsbs) |
| Alternative Antibody Names | Anti-Brisc And Brca1-A Complex Member 1 antibodyAnti-Mediator Of Rap80 Interactions And Targeting Subunit Of 40 Kda antibodyAnti-New Component Of The Brca1-A Complex antibodyAnti-BABAM1 antibodyAnti-C19orf62 antibodyAnti-MERIT40 antibodyAnti-NBA1 antibodyAnti-HSPC142 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
