| Tissue Specificity | Widely expressed. In adult, highly expressed in pancreas, placenta, fibroblast, thymus, prostate, testis, ovary and colon. Expressed at lower levels in spleen, small intestine and leukocytes. In fetus, expressed at high levels in the lung and kidney and at lower level in brain and liver. |
| Function | Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methyltransferase activity (Probable). |
| Protein Name | Probable Bifunctional Dttp/Utp Pyrophosphatase/Methyltransferase Protein Includes - Dttp/Utp PyrophosphataseDttpase/UtpaseNucleoside Triphosphate PyrophosphataseNucleotide PyrophosphataseNucleotide Ppase - N-Acetylserotonin O-Methyltransferase-Like ProteinAsmtl |
| Alternative Antibody Names | Anti-Probable Bifunctional Dttp/Utp Pyrophosphatase/Methyltransferase Protein Includes - Dttp/Utp Pyrophosphatase antibodyAnti-Dttpase/Utpase antibodyAnti-Nucleoside Triphosphate Pyrophosphatase antibodyAnti-Nucleotide Pyrophosphatase antibodyAnti-Nucleotide Ppase - N-Acetylserotonin O-Methyltransferase-Like Protein antibodyAnti-Asmtl antibodyAnti-ASMTL antibody |
Information sourced from Uniprot.org
