| Host: |
Rabbit |
| Applications: |
IHC |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ASIP (23-132) is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IHC-P 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ASIP |
| Gene ID: |
434 |
| Uniprot ID: |
ASIP_HUMAN |
| Immunogen Region: |
23-132 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 23-132 of human ASIP (NP_001663.2). |
| Immunogen Sequence: |
HLPPEEKLRDDRSLRSNSSV NLLDVPSVSIVALNKKSKQI GRKAAEKKRSSKKEASMKKV VRPRTPLSAPCVATRNSCKP PAPACCDPCASCQCRFFRSA CSCRVLSLNC |
| Tissue Specificity | Widely expressed at low levels. Highly expressed in the skin. Expressed in adipose tissue. |
| Function | Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes. |
| Protein Name | Agouti-Signaling ProteinAspAgouti Switch Protein |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Agouti-Signaling Protein antibodyAnti-Asp antibodyAnti-Agouti Switch Protein antibodyAnti-ASIP antibodyAnti-AGTI antibodyAnti-AGTIL antibodyAnti-ASP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
