| Host: |
Rabbit |
| Applications: |
IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SH2D1B (1-132) is suitable for use in Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IF 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SH2D1B |
| Gene ID: |
117157 |
| Uniprot ID: |
SH21B_HUMAN |
| Immunogen Region: |
1-132 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-132 of human SH2D1B (NP_444512.2). |
| Immunogen Sequence: |
MDLPYYHGRLTKQDCETLLL KEGVDGNFLLRDSESIPGVL CLCVSFKNIVYTYRIFREKH GYYRIQTAEGSPKQVFPSLK ELISKFEKPNQGMVVHLLKP IKRTSPSLRWRGLKLELETF VNSNSDYVDVLP |
| Function | Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244. In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation.downstream signaling involves PLCG1 and ERK activation. Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling. In the context of NK cell-mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse. Negatively regulates CD40-induced cytokine production in dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation. |
| Protein Name | Sh2 Domain-Containing Protein 1bEws/Fli1-Activated Transcript 2Eat-2 |
| Database Links | Reactome: R-HSA-198933 |
| Alternative Antibody Names | Anti-Sh2 Domain-Containing Protein 1b antibodyAnti-Ews/Fli1-Activated Transcript 2 antibodyAnti-Eat-2 antibodyAnti-SH2D1B antibodyAnti-EAT2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
