| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ASIC3 (62-320) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ASIC3 |
| Gene ID: |
9311 |
| Uniprot ID: |
ASIC3_HUMAN |
| Immunogen Region: |
62-320 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 62-320 of human ASIC3 (NP_064717.1). |
| Immunogen Sequence: |
ERVRYYREFHHQTALDERES HRLIFPAVTLCNINPLRRSR LTPNDLHWAGSALLGLDPAE HAAFLRALGRPPAPPGFMPS PTFDMAQLYARAGHSLDDML LDCRFRGQPCGPENFTTIFT RMGKCYTFNSGADGAELLTT TRGGMGNGLDIMLDVQQEEY LPVWRDNEETPFEVGIRVQI HSQEEPPIIDQLGLGVSPGY QTFVSCQQQQLSFLPPPWGD CSSASLNPNYEPEPSDPLG |
| Tissue Specificity | Expressed by sensory neurons. Strongly expressed in brain, spinal chord, lung, lymph nodes, kidney, pituitary, heart and testis. |
| Post Translational Modifications | Phosphorylated by PKA. Phosphorylated by PKC. In vitro, PRKCABP/PICK-1 is necessary for PKC phosphorylation and activation of a ASIC3/ACCN3-ASIC2/ASIC2b channel, but does not activate a homomeric ASIC3 channel. |
| Function | Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. |
| Protein Name | Acid-Sensing Ion Channel 3Asic3Hasic3Amiloride-Sensitive Cation Channel 3Neuronal Amiloride-Sensitive Cation Channel 3Testis Sodium Channel 1Htnac1 |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmCell Surface Expression May Be Stabilized By Interaction With Lin7b And Cytoplasmic Retention By Interaction With Dlg4In Part Cytoplasmic In Cochlea Cells |
| Alternative Antibody Names | Anti-Acid-Sensing Ion Channel 3 antibodyAnti-Asic3 antibodyAnti-Hasic3 antibodyAnti-Amiloride-Sensitive Cation Channel 3 antibodyAnti-Neuronal Amiloride-Sensitive Cation Channel 3 antibodyAnti-Testis Sodium Channel 1 antibodyAnti-Htnac1 antibodyAnti-ASIC3 antibodyAnti-ACCN3 antibodyAnti-SLNAC1 antibodyAnti-TNAC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
