| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ARL6 |
| Gene ID: | 84100 |
| Uniprot ID: | ARL6_HUMAN |
| Immunogen Region: | 1-186 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-186 of human ARL6 (NP_115522.1). |
| Immunogen Sequence: | MGLLDRLSVLLGLKKKEVHV LCLGLDNSGKTTIINKLKPS NAQSQNILPTIGFSIEKFKS SSLSFTVFDMSGQGRYRNLW EHYYKEGQAIIFVIDSSDRL RMVVAKEELDTLLNHPDIKH RRIPILFFANKMDLRDAVTS VKVSQLLCLENIKDKPWHIC ASDAIKGEGLQEGVDWLQDQ IQTVKT |
| Function | Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia. Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade. Isoform 2 may be required for proper retinal function and organization. |
| Protein Name | Adp-Ribosylation Factor-Like Protein 6 Bardet-Biedl Syndrome 3 Protein |
| Database Links | Reactome: R-HSA-5620922 |
| Cellular Localisation | Cell Projection Cilium Membrane Peripheral Membrane Protein Cytoplasmic Side Cytoplasm Cytoskeleton Cilium Axoneme Cilium Basal Body Appears In A Pattern Of Punctae Flanking The Microtubule Axoneme That Likely Correspond To Small Membrane-Associated Patches Localizes To The So-Called Ciliary Gate Where Vesicles Carrying Ciliary Cargo Fuse With The Membrane |
| Alternative Antibody Names | Anti-Adp-Ribosylation Factor-Like Protein 6 antibody Anti-Bardet-Biedl Syndrome 3 Protein antibody Anti-ARL6 antibody Anti-BBS3 antibody |
Information sourced from Uniprot.org