| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ARL6 (1-186) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ARL6 |
| Gene ID: |
84100 |
| Uniprot ID: |
ARL6_HUMAN |
| Immunogen Region: |
1-186 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-186 of human ARL6 (NP_115522.1). |
| Immunogen Sequence: |
MGLLDRLSVLLGLKKKEVHV LCLGLDNSGKTTIINKLKPS NAQSQNILPTIGFSIEKFKS SSLSFTVFDMSGQGRYRNLW EHYYKEGQAIIFVIDSSDRL RMVVAKEELDTLLNHPDIKH RRIPILFFANKMDLRDAVTS VKVSQLLCLENIKDKPWHIC ASDAIKGEGLQEGVDWLQDQ IQTVKT |
| Function | Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia. Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade. Isoform 2 may be required for proper retinal function and organization. |
| Protein Name | Adp-Ribosylation Factor-Like Protein 6Bardet-Biedl Syndrome 3 Protein |
| Database Links | Reactome: R-HSA-5620922 |
| Cellular Localisation | Cell ProjectionCilium MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytoskeletonCilium AxonemeCilium Basal BodyAppears In A Pattern Of Punctae Flanking The Microtubule Axoneme That Likely Correspond To Small Membrane-Associated PatchesLocalizes To The So-Called Ciliary Gate Where Vesicles Carrying Ciliary Cargo Fuse With The Membrane |
| Alternative Antibody Names | Anti-Adp-Ribosylation Factor-Like Protein 6 antibodyAnti-Bardet-Biedl Syndrome 3 Protein antibodyAnti-ARL6 antibodyAnti-BBS3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
