| Tissue Specificity | Widely expressed, with highest expression in spleen, followed by pancreas and lung. |
| Function | Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine.has a preference for tRNA(Gly). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis. |
| Protein Name | TrnaCarboxymethyluridine(34-5-O-Methyltransferase Alkbh8Alkylated Dna Repair Protein Alkb Homolog 8Alpha-Ketoglutarate-Dependent Dioxygenase Alkbh8S-Adenosyl-L-Methionine-Dependent Trna Methyltransferase Alkbh8 |
| Database Links | Reactome: R-HSA-6782315 |
| Cellular Localisation | CytoplasmNucleusPredominantly Cytoplasmic |
| Alternative Antibody Names | Anti-Trna antibodyAnti-Carboxymethyluridine(34-5-O-Methyltransferase Alkbh8 antibodyAnti-Alkylated Dna Repair Protein Alkb Homolog 8 antibodyAnti-Alpha-Ketoglutarate-Dependent Dioxygenase Alkbh8 antibodyAnti-S-Adenosyl-L-Methionine-Dependent Trna Methyltransferase Alkbh8 antibodyAnti-ALKBH8 antibodyAnti-ABH8 antibody |
Information sourced from Uniprot.org
