| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AGTRAP |
| Gene ID: | 57085 |
| Uniprot ID: | ATRAP_HUMAN |
| Immunogen Region: | 93-152 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 93-152 of human AGTRAP (NP_065083.3). |
| Immunogen Sequence: | ILSLLLKPLSCCFVYHMYRE RGGELLVHTGFLGSSQDRSA YQTIDSAEAPADPFAVPEGR |
| Tissue Specificity | Ubiquitous but more abundant in kidney, heart, pancreas and thyroid. |
| Function | Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity. |
| Protein Name | Type-1 Angiotensin Ii Receptor-Associated ProteinAt1 Receptor-Associated Protein |
| Database Links | Reactome: R-HSA-6802952 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneCytoplasmic Vesicle MembranePresent In Perinuclear Vesicular MembranesEndoplasmic ReticulumGolgi And Endocytic Vesicles |
| Alternative Antibody Names | Anti-Type-1 Angiotensin Ii Receptor-Associated Protein antibodyAnti-At1 Receptor-Associated Protein antibodyAnti-AGTRAP antibodyAnti-ATRAP antibody |
Information sourced from Uniprot.org