| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ADD2 |
| Gene ID: | 119 |
| Uniprot ID: | ADDB_HUMAN |
| Immunogen Region: | 580-690 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 580-690 of human ADD2 (NP_001171983.1). |
| Immunogen Sequence: | DGEKETAPEEPGSPAKSAPA SPVQSPAKEAETKSPLVSPS KSLEEGTKKTETSKAATTEP ETTQPEGVVVNGREEEQTAE EILSKGLSQMTTSADTDVDT SKDKTESVTSG |
| Tissue Specificity | Expressed mainly in brain, spleen, kidney cortex and medulla, and heart. Also expressed in human umbilical vein endothelial cells, human vascular smooth muscle cells, kidney tubular cells and K-562 cell line. |
| Post Translational Modifications | The N-terminus is blocked. |
| Function | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. |
| Protein Name | Beta-AdducinErythrocyte Adducin Subunit Beta |
| Database Links | Reactome: R-HSA-5223345 |
| Cellular Localisation | CytoplasmCytoskeletonCell MembranePeripheral Membrane ProteinCytoplasmic Side |
| Alternative Antibody Names | Anti-Beta-Adducin antibodyAnti-Erythrocyte Adducin Subunit Beta antibodyAnti-ADD2 antibodyAnti-ADDB antibody |
Information sourced from Uniprot.org