ACE2 and SARS-COV-2 research

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What is ACE2?

Angiotensin-converting enzyme 2 (ACE2) is an enzyme, that can be found attached to cell membranes of intestinal, heart, kidney and other cells. ACE2 is responsible for breaking down the angiotensinogen protein into smaller ones, which go on and regulate cell functions. This enzyme exists in both membrane bound and soluble form and it is a key component of the Renin Angiotensin Aldosterone System (RAAS), which maintains the blood pressure and the fluid and electrolyte balance in the human body. 

ACE2 and coronavirus cell entry.

The membrane form of this enzyme (mACE2) serves as an entry point to some coronaviruses, most notably SARS-CoV and SARS-CoV-2. The spike protein, located on the surface of the SARS-CoV-2 virus has been examined to cause damage to the cell epithelium, by down regulation of the human ACE2 enzyme (hACE2).

 

  We offer a variety of ACE2 antibodies, proteins and ELISA kits to support your research. 

ACE2 related antibodies

Image Name Host Application Clonality
Anti-ACE2 antibody (Internal) (STJ91442) Rabbit WB, ELISA Polyclonal
Anti-ACE2-antibody [ARC1051] (STJ11102116) Rabbit WB, IHC Monoclonal
Anti-SARS-CoV-2-S-Protein ACE 2 Binding Domain antibody [5G8] (STJ120310) Mouse WB, ICC Monoclonal

ACE2 related ELISA kits

ACE2 related proteins