• Rat Trx (Thioredoxin) Sandwich ELISA Kit Ready-To-Use (STJE0019218)

Rat Trx (Thioredoxin) Sandwich ELISA Kit Ready-To-Use (STJE0019218)

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STJE0019218

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Applications: ELISA
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.137ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This Trx Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Txn
Gene ID: 116484
Uniprot ID: THIO_RAT
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma or other biological fluids.
Tissue Specificity
Post Translational Modifications In the fully reduced protein, both Cys-69 and Cys-73 are nitrosylated in response to nitric oxide (NO). When two disulfide bonds are present in the protein, only Cys-73 is nitrosylated. Cys-73 can serve as donor for nitrosylation of target proteins.
Function Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.
Protein Name Thioredoxin
Trx
Database Links Reactome: R-RNO-2559580
Reactome: -RNO-3299685
Reactome: -RNO-499943
Reactome: -RNO-5628897
Reactome: -RNO-5676934
Reactome: -RNO-844456
Cellular Localisation Nucleus
Cytoplasm
Secreted
Translocates From The Cytoplasm Into The Nucleus After Phorbol 12-Myristate 13-Acetate Induction (Pma)
Predominantly In The Cytoplasm In Non Irradiated Cells
Radiation Induces Translocation Of Trx From The Cytoplasm To The Nucleus
Secreted By A Leaderless Secretory Pathway
Alternative ELISA Names Thioredoxin ELISA kit
Trx ELISA kit
Txn ELISA kit
Txn1 ELISA kit
output

Information sourced from Uniprot.org

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