| Applications: |
ELISA |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.113ng/mL |
| Detection Limit: |
0.312-20ng/mL |
| Short Description: |
This PXR Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
Nr1i2 |
| Gene ID: |
84385 |
| Uniprot ID: |
NR1I2_RAT |
| Sample Type: |
tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | |
| Function | Nuclear receptor that binds and is activated by a variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, endogenous compounds and drugs. Response to specific ligands is species-specific, due to differences in the ligand-binding domain. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. |
| Protein Name | Nuclear Receptor Subfamily 1 Group I Member 2Orphan Nuclear Receptor PxrPregnane X Receptor |
| Database Links | Reactome: R-RNO-383280Reactome: -RNO-4090294 |
| Cellular Localisation | Nucleus |
| Alternative ELISA Names | Nuclear Receptor Subfamily 1 Group I Member 2 ELISA kitOrphan Nuclear Receptor Pxr ELISA kitPregnane X Receptor ELISA kitNr1i2 ELISA kitPxr ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
