• Rat OPTN (Optineurin) Sandwich ELISA Kit Ready-To-Use (STJE0017592)

Rat OPTN (Optineurin) Sandwich ELISA Kit Ready-To-Use (STJE0017592)

SKU:
STJE0017592

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Applications: ELISA
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 32.4pg/mL
Detection Limit: 78.1-5000pg/mL
Short Description: This OPTN Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Optn
Gene ID: 246294
Uniprot ID: OPTN_RAT
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications Phosphorylated by TBK1, leading to restrict bacterial proliferation in case of infection.
Function Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR).regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family.targets ubiquitin-coated bacteria (xenophagy) and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52.
Protein Name Optineurin
Fip-2-Like Protein
Database Links Reactome: R-RNO-2565942
Reactome: -RNO-5357905
Reactome: -RNO-5357956
Reactome: -RNO-8854214
Cellular Localisation Cytoplasm
Perinuclear Region
Golgi Apparatus
Trans-Golgi Network
Cytoplasmic Vesicle
Autophagosome
Recycling Endosome
Found In The Perinuclear Region And Associates With The Golgi Apparatus
Colocalizes With Myo6 And Rab8 At The Golgi Complex And In Vesicular Structures Close To The Plasma Membrane
Localizes To Lc3-Positive Cytoplasmic Vesicles Upon Induction Of Autophagy
Alternative ELISA Names Optineurin ELISA kit
Fip-2-Like Protein ELISA kit
Optn ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance