| Applications: |
ELISA |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.25ng/mL |
| Detection Limit: |
0.781-50ng/mL |
| Short Description: |
This OAS1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
3 hrs |
| Gene Symbol: |
Oas1a |
| Gene ID: |
192281 |
| Uniprot ID: |
OAS1A_RAT |
| Immunogen Region: |
Ready-To-Use |
| Sample Type: |
serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | |
| Function | Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. |
| Protein Name | 2'-5'-Oligoadenylate Synthase 1a(2-5'Oligo(A Synthase 1a2-5a Synthase 1a |
| Database Links | |
| Cellular Localisation | CytoplasmMitochondrionNucleusMicrosomeEndoplasmic ReticulumAssociated With Different Subcellular Fractions Such As MitochondrialNuclearAnd Rough/Smooth Microsomal Fractions |
| Alternative ELISA Names | 2'-5'-Oligoadenylate Synthase 1a ELISA kit(2-5'Oligo(A Synthase 1a ELISA kit2-5a Synthase 1a ELISA kitOas1a ELISA kitOas1 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
