| Applications: |
ELISA |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.063ng/mL |
| Detection Limit: |
0.156-10ng/mL |
| Short Description: |
This NRP1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
Nrp1 |
| Gene ID: |
246331 |
| Uniprot ID: |
NRP1_RAT |
| Sample Type: |
tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Found in the embryonic nervous system. Expressed in dorsal root ganglia. |
| Post Translational Modifications | |
| Function | Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins. Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR. |
| Protein Name | Neuropilin-1Vascular Endothelial Cell Growth Factor 165 ReceptorCd Antigen Cd304 |
| Database Links | Reactome: R-RNO-194306Reactome: -RNO-399954Reactome: -RNO-399955Reactome: -RNO-399956Reactome: -RNO-445144 |
| Cellular Localisation | Mitochondrion MembraneSingle-Pass Type I Membrane ProteinCell MembraneCytoplasm |
| Alternative ELISA Names | Neuropilin-1 ELISA kitVascular Endothelial Cell Growth Factor 165 Receptor ELISA kitCd Antigen Cd304 ELISA kitNrp1 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
