| Applications: |
ELISA |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.064ng/mL |
| Detection Limit: |
0.156-10ng/mL |
| Short Description: |
This MR Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
Nr3c2 |
| Gene ID: |
25672 |
| Uniprot ID: |
MCR_RAT |
| Sample Type: |
tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Detected in liver, brain, heart, kidney, colon, aorta, hippocampus, hypothalamus and adrenal fasciculata. |
| Post Translational Modifications | Phosphorylated. |
| Function | Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. |
| Protein Name | Mineralocorticoid ReceptorMrNuclear Receptor Subfamily 3 Group C Member 2 |
| Database Links | Reactome: R-RNO-3371497Reactome: -RNO-383280Reactome: -RNO-4090294 |
| Cellular Localisation | CytoplasmNucleusEndoplasmic Reticulum MembranePeripheral Membrane ProteinCytoplasmic And Nuclear In The Absence Of LigandNuclear After Ligand-BindingWhen Bound To Hsd11b2It Is Found Associated With The Endoplasmic Reticulum Membrane |
| Alternative ELISA Names | Mineralocorticoid Receptor ELISA kitMr ELISA kitNuclear Receptor Subfamily 3 Group C Member 2 ELISA kitNr3c2 ELISA kitMlr ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
