Host: |
HEK293 cells |
Reactivity: |
Rat |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Recombinant-Rat MMP-9-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of 50mM TRIS, 10mM CaCl2, 150mM NaCl, pH 7.5. Contact us for customized product form or formulation. |
Immunoreactivity: |
Measured in a cell migration assay using Hela cells.1 ng/mL of Recombinant Rat MMP-9 can effectively induce Hela cells migration.2. Measured by its ability to cleave the fluorogenic peptide substrate Mca-PLGL-Dpa-AR-NH2. The specific activity is >160 |
Gene Symbol: |
Mmp9 |
Gene ID: |
81687 |
Uniprot ID: |
MMP9_RAT |
Immunogen Region: |
Leu35-Pro708 |
Immunogen: |
Recombinant Rat MMP-9 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu35-Pro708) of rat MMP-9 (Accession #NP_038627.1.) fused with a 6Ă—His tag at the C-terminus. |
Post Translational Modifications | N- and O-glycosylated. |
Function | Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves NINJ1 to generate the Secreted ninjurin-1 form. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide. |
Protein Name | Matrix Metalloproteinase-9Mmp-992 Kda Gelatinase92 Kda Type Iv CollagenaseGelatinase BGelb |
Database Links | Reactome: R-RNO-1433557Reactome: -RNO-1442490Reactome: -RNO-1474228Reactome: -RNO-1592389Reactome: -RNO-2022090Reactome: -RNO-3928665Reactome: -RNO-6798695Reactome: -RNO-9009391 |
Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
Alternative Protein Names | Matrix Metalloproteinase-9 proteinMmp-9 protein92 Kda Gelatinase protein92 Kda Type Iv Collagenase proteinGelatinase B proteinGelb proteinMmp9 protein |
Information sourced from Uniprot.org
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