| Applications: |
ELISA |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.117ng/mL |
| Detection Limit: |
0.312-20ng/mL |
| Short Description: |
This DIO3 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
3 hrs |
| Gene Symbol: |
Dio3 |
| Gene ID: |
29475 |
| Uniprot ID: |
IOD3_RAT |
| Immunogen Region: |
Ready-To-Use |
| Sample Type: |
tissue homogenates or other biological fluids. |
| Tissue Specificity | Neonatal skin, placenta, skeletal muscle and cerebral cortex. |
| Post Translational Modifications | |
| Function | Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development. |
| Protein Name | Thyroxine 5-Deiodinase5diiiDioiiiType 3 DiType Iii Iodothyronine Deiodinase |
| Database Links | Reactome: R-RNO-350864 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinEndosome Membrane |
| Alternative ELISA Names | Thyroxine 5-Deiodinase ELISA kit5diii ELISA kitDioiii ELISA kitType 3 Di ELISA kitType Iii Iodothyronine Deiodinase ELISA kitDio3 ELISA kitItdi3 ELISA kitTxdi3 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
