| Applications: |
ELISA |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
8.7ng/mL |
| Detection Limit: |
15.6-1000ng/mL |
| Short Description: |
This a2M Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
3 hrs |
| Gene Symbol: |
A2m |
| Gene ID: |
24153 |
| Uniprot ID: |
A2MG_RAT |
| Immunogen Region: |
Ready-To-Use |
| Sample Type: |
serum, plasma, urine or other biological fluids. |
| Tissue Specificity | Highest constitutive expression in ovary. Low level in testis, uterus and non-acute phase liver. Protein found in plasma. |
| Post Translational Modifications | |
| Function | Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. |
| Protein Name | Alpha-2-MacroglobulinAlpha-2-M |
| Database Links | Reactome: R-RNO-114608Reactome: -RNO-140837Reactome: -RNO-1474228Reactome: -RNO-8963896 |
| Cellular Localisation | Secreted |
| Alternative ELISA Names | Alpha-2-Macroglobulin ELISA kitAlpha-2-M ELISA kitA2m ELISA kitA2m1 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
