Mouse TNFRSF6/CD95/FAS protein (Recombinant) (C-6×His) (STJP002660)

SKU:
STJP002660

$137.03 - $386.78
Current Stock:
Host: HEK293 cells
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Mouse TNFRSF6/CD95/FAS-C-6×His protein was developed from hek293 cells and has a target region of C-6×His. For use in research applications.
Formulation: Lyophilized from a 0.2 Mu m filtered solution of PBS, pH7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Fas
Gene ID: 14102
Uniprot ID: TNR6_MOUSE
Immunogen Region: Gln22-Arg169
Immunogen: Recombinant Mouse TNFRSF6/CD95/FAS Protein is produced by Human Cells expression system. The target protein is expressed with sequence (Gln22-Arg169) of mouse TNFRSF6/CD95/FAS (Accession #P25446) fused with a 6×His tag at the C-terminus.
Post Translational Modifications Palmitoylated. Palmitoylation by ZDHHC7 prevents the lysosomal degradation of FAS regulating its expression at the plasma membrane.
Function Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.
Protein Name Tumor Necrosis Factor Receptor Superfamily Member 6
Apo-1 Antigen
Apoptosis-Mediating Surface Antigen Fas
Faslg Receptor
Cd Antigen Cd95
Database Links Reactome: R-MMU-3371378
Reactome: -MMU-5218900
Reactome: -MMU-69416
Reactome: -MMU-75157
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Membrane Raft
Alternative Protein Names Tumor Necrosis Factor Receptor Superfamily Member 6 protein
Apo-1 Antigen protein
Apoptosis-Mediating Surface Antigen Fas protein
Faslg Receptor protein
Cd Antigen Cd95 protein
Fas protein
Apt1 protein
Tnfrsf6 protein

Information sourced from Uniprot.org

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