| Host: |
HEK293 cells |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Mouse TIMP-1-No tag protein was developed from hek293 cells and has a target region of No tag. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Normally 5 %-8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: |
Measured by its ability to inhibit human MMP-2 cleavage of a fluorogenic peptide substrate MCA-PLGL-DPA-AR-NH2. The IC50 value is |
| Gene Symbol: |
Timp1 |
| Gene ID: |
21857 |
| Uniprot ID: |
TIMP1_MOUSE |
| Immunogen Region: |
Met 1-Arg 205 |
| Immunogen: |
Recombinant Mouse TIMP-1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met 1-Arg 205) of Mouse TIMP-1 (Accession #NP_035723.2) fused with no tag. |
| Post Translational Modifications | The activity of TIMP1 is dependent on the presence of disulfide bonds. N-glycosylated. |
| Function | Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. |
| Protein Name | Metalloproteinase Inhibitor 1Collagenase Inhibitor 16c8 FibroblastErythroid-Potentiating ActivityEpaTpa-S1Tpa-Induced ProteinTissue Inhibitor Of Metalloproteinases 1Timp-1 |
| Database Links | Reactome: R-MMU-114608Reactome: -MMU-1592389Reactome: -MMU-381426Reactome: -MMU-8957275 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Metalloproteinase Inhibitor 1 proteinCollagenase Inhibitor 16c8 Fibroblast proteinErythroid-Potentiating Activity proteinEpa proteinTpa-S1 proteinTpa-Induced Protein proteinTissue Inhibitor Of Metalloproteinases 1 proteinTimp-1 proteinTimp1 proteinTimp proteinTimp-1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
