| Applications: |
ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
31pg/mL |
| Detection Limit: |
78.1-5000pg/mL |
| Short Description: |
This SCGN Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
Stmn2 |
| Gene ID: |
20257 |
| Uniprot ID: |
STMN2_MOUSE |
| Sample Type: |
serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | Neuron specific. |
| Post Translational Modifications | Sumoylated. Phosphorylated mostly by MAPK8, but also by MAPK9 and MAPK10 in the developing brain cortex. N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15. |
| Function | Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone. |
| Protein Name | Stathmin-2Superior Cervical Ganglion-10 ProteinProtein Scg10 |
| Database Links | Reactome: R-MMU-9696273 |
| Cellular Localisation | CytoplasmPerinuclear RegionCell ProjectionGrowth ConeAxonMembranePeripheral Membrane ProteinCytoplasmic SideEndosomeGolgi ApparatusLamellipodiumColocalized With Cib1 In Neurites Of Developing Hippocampal Primary NeuronsColocalized With Cib1 In The Cell BodyNeuritisGrowth Cones Of Neurons And In Neurites Of Developing Hippocampal Primary NeuronsColocalized With Cib1 To The Leading Edge Of LamellipodiaAssociated With Punctate Structures In The Perinuclear CytoplasmAxonsAnd Growth Cones Of Developing NeuronsExists In Both Soluble And Membrane-Bound FormsIn The Developing BrainMostly Cytosolic |
| Alternative ELISA Names | Stathmin-2 ELISA kitSuperior Cervical Ganglion-10 Protein ELISA kitProtein Scg10 ELISA kitStmn2 ELISA kitScg10 ELISA kitScgn10 ELISA kitStmb2 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
