| Applications: |
ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
14.2pg/mL |
| Detection Limit: |
31.2-2000pg/mL |
| Short Description: |
This S100A4 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
S100a4 |
| Gene ID: |
20198 |
| Uniprot ID: |
S10A4_MOUSE |
| Sample Type: |
serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
| Tissue Specificity | Specifically expressed in different metastatic cells. |
| Post Translational Modifications | |
| Function | Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy. Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9. Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis. Modulates also the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels. Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes. In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors. |
| Protein Name | Protein S100-A4MetastasinMetastatic Cell ProteinPel98Placental Calcium-Binding ProteinProtein 18a2Protein Mts1S100 Calcium-Binding Protein A4 |
| Database Links | |
| Cellular Localisation | SecretedNucleusCytoplasm |
| Alternative ELISA Names | Protein S100-A4 ELISA kitMetastasin ELISA kitMetastatic Cell Protein ELISA kitPel98 ELISA kitPlacental Calcium-Binding Protein ELISA kitProtein 18a2 ELISA kitProtein Mts1 ELISA kitS100 Calcium-Binding Protein A4 ELISA kitS100a4 ELISA kitCapl ELISA kitMts1 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
