• Mouse RYR1 (Ryanodine Receptor 1, Skeletal) Sandwich ELISA Kit (STJE0011961)

Mouse RYR1 (Ryanodine Receptor 1, Skeletal) Sandwich ELISA Kit (STJE0011961)

SKU:
STJE0011961

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Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.072ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This RYR1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Ryr1
Gene ID: 20190
Uniprot ID: RYR1_MOUSE
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Detected in muscle and myotubes (at protein level). Ubiquitous. Detected in diaphragm, skeletal muscle, esophagus, spleen, submaxillary gland, adrenal gland, cerebellum, brain and in testis germ cells.
Post Translational Modifications Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2844 may increase channel activity. Repeated very high-level exercise increases phosphorylation at Ser-2844. Activated by reversible S-nitrosylation. Repeated very high-level exercise increases S-nitrosylation.
Function Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis.
Protein Name Ryanodine Receptor 1
Ryr-1
Ryr1
Skeletal Muscle Calcium Release Channel
Skeletal Muscle Ryanodine Receptor
Skeletal Muscle-Type Ryanodine Receptor
Type 1 Ryanodine Receptor
Database Links Reactome: R-MMU-2672351
Reactome: -MMU-5578775
Cellular Localisation Sarcoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
The Number Of Predicted Transmembrane Domains Varies Between Orthologs
Both N-Terminus And C-Terminus Are Cytoplasmic
Alternative ELISA Names Ryanodine Receptor 1 ELISA kit
Ryr-1 ELISA kit
Ryr1 ELISA kit
Skeletal Muscle Calcium Release Channel ELISA kit
Skeletal Muscle Ryanodine Receptor ELISA kit
Skeletal Muscle-Type Ryanodine Receptor ELISA kit
Type 1 Ryanodine Receptor ELISA kit
Ryr1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance