• Mouse PR3 (Proteinase 3) Sandwich ELISA Kit Ready-To-Use (STJE0018020)

Mouse PR3 (Proteinase 3) Sandwich ELISA Kit Ready-To-Use (STJE0018020)

SKU:
STJE0018020

£472.50 - £647.50
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Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.058ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This PR3 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Prtn3
Gene ID: 19152
Uniprot ID: PRTN3_MOUSE
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications
Function Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration. May play a role in neutrophil transendothelial migration, probably when associated with CD177.
Protein Name Myeloblastin
Proteinase 3
Pr-3
Database Links Reactome: R-MMU-140875
Reactome: -MMU-6798695
Reactome: -MMU-6803157
Cellular Localisation Lysosome
Secreted
Cell Membrane
Peripheral Membrane Protein
Extracellular Side
Membrane Raft
Localizes Predominantly To Azurophil Granules (Primary Secretory Granules) In Neutrophils
Secreted Upon Neutrophil Stimulation By Tnf-Alpha
Lipopolysaccharide (Lps)
Fmlp And Cxcl8/Il8 Or During Neutrophil Transmigration
Following Secretion Tethered To The Cell Membrane By Cd177
Alternative ELISA Names Myeloblastin ELISA kit
Proteinase 3 ELISA kit
Pr-3 ELISA kit
Prtn3 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance