| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Mouse PIK3R1/PI3-kinase p85-alpha-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | Pik3r1 |
| Gene ID: | 18708 |
| Uniprot ID: | P85A_MOUSE |
| Immunogen Region: | Trp624-Val718 |
| Immunogen: | Mus musculus (Mouse) |
| Function | Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement. |
| Protein Name | Phosphatidylinositol 3-Kinase Regulatory Subunit AlphaPi3-Kinase Regulatory Subunit AlphaPi3k Regulatory Subunit AlphaPtdins-3-Kinase Regulatory Subunit AlphaPhosphatidylinositol 3-Kinase 85 Kda Regulatory Subunit AlphaPi3-Kinase Subunit P85-AlphaPtdins-3-Kinase Regulatory Subunit P85-Alpha |
| Database Links | Reactome: R-MMU-109704Reactome: -MMU-112399Reactome: -MMU-114604Reactome: -MMU-1250342Reactome: -MMU-1257604Reactome: -MMU-1266695Reactome: -MMU-1433557Reactome: -MMU-1660499Reactome: -MMU-180292Reactome: -MMU-186763Reactome: -MMU-1963642Reactome: -MMU-198203Reactome: -MMU-201556Reactome: -MMU-202424Reactome: -MMU-2029485Reactome: -MMU-210993Reactome: -MMU-2424491Reactome: -MMU-2730905Reactome: -MMU-388841Reactome: -MMU-389357Reactome: -MMU-416476Reactome: -MMU-430116Reactome: -MMU-4420097Reactome: -MMU-512988Reactome: -MMU-5654689Reactome: -MMU-5654695Reactome: -MMU-5654710Reactome: -MMU-5654720Reactome: -MMU-5673001Reactome: -MMU-6811558Reactome: -MMU-8851907Reactome: -MMU-8853659Reactome: -MMU-8980692Reactome: -MMU-9009391Reactome: -MMU-9013026Reactome: -MMU-9013106Reactome: -MMU-9013148Reactome: -MMU-9013149Reactome: -MMU-9013404Reactome: -MMU-9013405Reactome: -MMU-9013408Reactome: -MMU-9013409Reactome: -MMU-9013420Reactome: -MMU-9013423Reactome: -MMU-9013424Reactome: -MMU-9027276Reactome: -MMU-9035034Reactome: -MMU-912526Reactome: -MMU-912631Reactome: -MMU-9607240Reactome: -MMU-9696264Reactome: -MMU-9696270Reactome: -MMU-9696273Reactome: -MMU-983695Reactome: -MMU-9842663 |
| Alternative Protein Names | Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha proteinPi3-Kinase Regulatory Subunit Alpha proteinPi3k Regulatory Subunit Alpha proteinPtdins-3-Kinase Regulatory Subunit Alpha proteinPhosphatidylinositol 3-Kinase 85 Kda Regulatory Subunit Alpha proteinPi3-Kinase Subunit P85-Alpha proteinPtdins-3-Kinase Regulatory Subunit P85-Alpha proteinPik3r1 protein |
Information sourced from Uniprot.org
