• Mouse PICK1 (Protein Interacting With Protein Kinase C Alpha 1) Sandwich ELISA Kit Ready-To-Use (STJE0017839)

Mouse PICK1 (Protein Interacting With Protein Kinase C Alpha 1) Sandwich ELISA Kit Ready-To-Use (STJE0017839)

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STJE0017839

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Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.053ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This PICK1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Pick1Uniprot ID=PICK1_MOUSE"
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Expressed in all tissues examined, with highest levels in brain and testes and lowest levels in lung.
Post Translational Modifications Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors. Phosphorylated on tyrosine residues by EPHB2 and on serine or threonine residues by PKC. Palmitoylation on Cys-414 is essential for long-term synaptic depression (LTD).
Function Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex.the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.
Protein Name Prkca-Binding Protein
Protein Interacting With C Kinase 1
Protein Kinase C-Alpha-Binding Protein
Database Links
Cellular Localisation Cytoplasm
Perinuclear Region
Membrane
Peripheral Membrane Protein
Lipid-Anchor
Postsynaptic Density
Synapse
Synaptosome
Cytoskeleton
Also Membrane-Associated
Present At Excitatory Synapses
Alternative ELISA Names Prkca-Binding Protein ELISA kit
Protein Interacting With C Kinase 1 ELISA kit
Protein Kinase C-Alpha-Binding Protein ELISA kit
Pick1 ELISA kit
Prkcabp ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance