| Applications: |
ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.067ng/mL |
| Detection Limit: |
0.156-10ng/mL |
| Short Description: |
This NOX4 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
Nox4 |
| Gene ID: |
50490 |
| Uniprot ID: |
NOX4_MOUSE |
| Sample Type: |
tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | EXpressed in brain, in all layers of the cerebellum, in pyramidal cells of the Ammon horn and in Purkinje cells (at protein level). Expressed in osteoclasts, leukocytes, kidney, liver and lung. |
| Post Translational Modifications | N-glycosylation is required for the function. |
| Function | Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. |
| Protein Name | Nadph Oxidase 4Kidney Oxidase-1Kox-1Kidney Superoxide-Producing Nadph OxidaseRenal Nad(Ph-OxidaseSuperoxide-Generating Nadph Oxidase 4 |
| Database Links | Reactome: R-MMU-3299685 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinCell JunctionFocal AdhesionCell MembraneMay Localize To Plasma Membrane And Focal Adhesions |
| Alternative ELISA Names | Nadph Oxidase 4 ELISA kitKidney Oxidase-1 ELISA kitKox-1 ELISA kitKidney Superoxide-Producing Nadph Oxidase ELISA kitRenal Nad(Ph-Oxidase ELISA kitSuperoxide-Generating Nadph Oxidase 4 ELISA kitNox4 ELISA kitRenox ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
