| Applications: |
ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.087ng/mL |
| Detection Limit: |
0.312-20ng/mL |
| Short Description: |
This MUC4 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
Muc4 |
| Gene ID: |
140474 |
| Uniprot ID: |
MUC4_MOUSE |
| Sample Type: |
tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
| Tissue Specificity | Expressed in trachea, duodenum and intestine. Lower expression in stomach, salivary glands, liver, gallbladder, and kidney. |
| Post Translational Modifications | Proteolytically cleaved into 2 chains, mucin-4 alpha chain and mucin-4 beta chain. Mucin-4 alpha chain: Highly O-glycosylated. Mucin-4 beta chain: Predominantly N-glycosylated. |
| Function | Membrane-bound mucin, a family of highly glycosylated proteins that constitute the major component of the mucus, the slimy and viscous secretion covering epithelial surfaces. These glycoproteins play important roles in the protection of the epithelium and are implicated in epithelial renewal and differentiation. Regulates cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and its ability to act as an intramembrane ligand for ERBB2. Plays an important role in proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. In polarized epithelial cells, segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. Its ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. |
| Protein Name | Mucin-4Muc-4Ascites SialoglycoproteinAsgpPancreatic Adenocarcinoma MucinTestis Mucin Cleaved Into - Mucin-4 Alpha ChainAscites Sialoglycoprotein 1Asgp-1 - Mucin-4 Beta ChainAscites Sialoglycoprotein 2Asgp-2 |
| Database Links | Reactome: R-MMU-913709Reactome: -MMU-977068 |
| Cellular Localisation | Mucin-4 Beta Chain: Cell MembraneSingle-Pass Membrane ProteinIsoforms Lacking The Cys-Rich RegionEgf-Like Domains And Transmembrane Region Are SecretedSecretion Occurs By Splicing Or Proteolytic ProcessingMucin-4 Alpha Chain: Cell MembraneSecretedForms A Complex With Mucin-4 Beta Chain At The Cell Membrane |
| Alternative ELISA Names | Mucin-4 ELISA kitMuc-4 ELISA kitAscites Sialoglycoprotein ELISA kitAsgp ELISA kitPancreatic Adenocarcinoma Mucin ELISA kitTestis Mucin Cleaved Into - Mucin-4 Alpha Chain ELISA kitAscites Sialoglycoprotein 1 ELISA kitAsgp-1 - Mucin-4 Beta Chain ELISA kitAscites Sialoglycoprotein 2 ELISA kitAsgp-2 ELISA kitMuc4 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
